Poziotinib

Poziotinib is an investigational drug not approved by the FDA.

Poziotinib is an investigational, orally administered, irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations.

> To read the latest news about poziotinib, or to watch a video on its mechanism, click here.

Poziotinib is designed to be small and flexible. HER2

Poziotinib is an investigational drug not approved by the FDA.

A variety of mutations in EGFR result in their constant activation, and are associated with certain cancers. Among the known activating mutations in HER2, <br />exon 20 insertions add additional amino acids to the protein sequence causing a conformational change, heavily restricting access to the drug binding pocket of the kinase active site. Preclinical studies suggest that poziotinib can access the restricted binding pocket caused by these exon 20 insertion mutations and may help inhibit its kinase activity.

In pre-clinical models of cancer, poziotinib was shown to inhibit kinase activity of EGFR and HER2 with exon 20 insertion mutations, inhibiting proliferation, leading to cancer cell death.

More About Poziotinib

Breast Cancer
SPI-POZ-201 (Phase 2): HER2+ Metastatic Breast Cancer

Latest News on Poziotinib

See all press releases