Poziotinib

Poziotinib is an investigational drug not yet approved by the FDA.


Poziotinib is an investigational, orally administered, irreversible tyrosine kinase inhibitor targeting EGFR and HER2 with exon 20 insertion mutations.

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Poziotinib is designed to be small and flexible.

Poziotinib is an investigational drug not yet approved by the FDA.


In pre-clinical models of cancer, poziotinib was shown to inhibit kinase activity of EGFR and HER2 with exon 20 insertion mutations, inhibiting proliferation, leading to cancer cell death.

More About Poziotinib

Development Indications

Non Small Cell Lung Cancer
SPI-POZ-202 (Phase 2): EGFR and HER2 Exon 20 Insertion Mutations Locally Advanced or Metastatic NSCLC

Breast Cancer
SPI-POZ-201 (Phase 2): HER2+ Metastatic Breast Cancer
SPI-POZ-101 (Phase 1b) Combination With T-DM1 in HER2+ Breast Cancer

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