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SPI-376


Target Indications
  • Schizophrenia

Route of Administration
  • Oral

SPI-376 Status
  • Preclinical

SPI-376 - Pharmacological Drug in Development

SPI-376 Activity Profile

In animal studies to date:
  • Reverses phencyclidine-induced disruption of pre-pulse inhibition (psychosis model)
  • Does not disrupt conditioned avoidance responding (cognition model)
  • Novel receptor profile as compared to the currently available antipsychotics
  • Data suggests that this compound is a D4-dopaminergic receptor antagonist and a 5-HT1A-serotonergic receptor agonist
  • Good safety profile and therapeutic index

Schizophrenia Market

An estimated 2 million Americans or 1% of the American population is affected by schizophrenia. Both men and women are affected in equal numbers, although onset is slightly later in women. People with schizophrenia suffer severe disturbances in thinking, social and emotions such as hearing internal voices not heard by others, or believing that other people are reading their minds, controlling their thoughts or plotting to harm them.

While there are available treatments that can relieve some of the symptoms, these medications cause significant side effects such as involuntary motor activity, weight gain, and social withdrawal.

SPI-376 is available for outlicensing.


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